Antibiotic resistance is a growing concern worldwide, and it is causing a lot of health complications. Traditional antibiotics are losing their efficacy due to overuse and misuse, and the accumulation of antibiotic-resistant bacteria. Consequently, the search for alternative therapeutic options is becoming necessary. One such alternative therapeutic option that has shown promising results is the use of natural products.
The peel of Citrus limon (L.) Burm has a rich content of phytochemicals, which have been reported to possess antibacterial properties. A recent study investigated the in vitro antibacterial activity of Citrus limon (L.) Burm peel extract against gentamicin-resistant Escherichia coli. The study found that the peel extract showed significant antibacterial activity against the test strain.
Additionally, the study conducted in silico molecular docking of the major phytochemicals in Citrus limon (L.) Burm with the ribosome recycling factor. The result of the docking revealed that these phytochemicals have a high binding affinity for the ribosome recycling factor, which may be the mechanism by which they exert their antibacterial activity.
One major advantage of using natural products as alternatives to traditional antibiotics is that they have less adverse effects compared to traditional antibiotics. They also have a more diverse range of active compounds, making them less susceptible to the development of antibiotic resistance.
In conclusion, the use of Citrus limon (L.) Burm peel extract in the treatment of bacterial infections presents a promising alternative therapeutic option. With increasing concerns about antibiotic resistance, the search for natural products with antibacterial activity should be encouraged. Finally, more research is needed to explore the full potential of Citrus limon (L.) Burm peel extract in the treatment of bacterial infections.